Publications and Patents



Discoveries from the Inflammasome Lab have been published in a range of top journals in the fields of cell biology, molecular biology, inflammation and immunology.



Impact Metrics

Prof Kate Schroder's H-index = 46
Citations =  >16,000 (Google Scholar)
Total number of publications = 100
76 research articles, 22 reviews/commentaries, 2 book chapters
Publications with >3300 cites = 2,  >100 cites = 29
F1000 recommendations = 8
Essential Science Indicators highly cited articles = 9

Awards and Commentaries

Boucher et al 2018 was highlighted by Journal of Experimental Medicine and featured in 2 TV news stories, and media from 16 international news outlets. Chen, Monteleone, Boucher et al 2018 was highlighted by Nature Reviews Rheumatology. Baker et al 2015 was the subject of a European J Immunol commentary. Coll et al 2015 Nature Medicine was the subject of 7 commentaries/highlights and media from 25 international news outlets. Schroder et al 2012 was highlighted by Nature Asia. Schroder et al 2010 Cell was a 2010 Science Direct’s Annual Top25 article. Schroder et al 2004 J Leuk Biol received the Dolph Adams Award, and is the most-cited article ever published by the journal.

Patents and Therapies

Small molecule inflammasome inhibitors co-invented by Inflammasome Lab and collaborators are the subject of three international patent families.
These inhibitors are currently under commercialisation as novel anti-inflammatory compounds for multiple diseases, by the biotech company, Inflazome Ltd.
Inflazome Ltd recently secured further investment of AUD$63 million to advance small molecule inflammasome inhibitors to clinical trials, commencing in 2019. These are now under translation to the clinic by Roche for treatment of inflammatory and neurodegenerative diseases. Read the announcement here.




128. Lawrence GMEP, Holley CL, Schroder K (2022).
Parkinson's disease: connecting mitochondria to inflammasomes. Trends in Immunology Nov;43(11):877-885. Pubmed


127. Lawrence GMEP, Holley CL, Schroder K (2022).
Come on mtDNA, light my fire. Immunity Aug 9;55(8):1331-1333. Pubmed


126. Donovan C, Kim RY, Galvao I, Jarnicki AG, Brown AC, Jones-Freeman B, Gomez HM, Wadhwa R, Hortle E, Jayaraman R, Khan H, Pickles S, Sahu P, Chimankar V, Tu X, Ali MK, Mayall JR, Nguyen DH, Budden KF, Kumar V, Schroder K, Robertson AA, Cooper MA, Wark PA, Oliver BG, Horvat JC, Hansbro PM (2022).
Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion. Immunology and Cell Biology Apr;100(4):235-249. Pubmed


125. Bonfim-Melo A, Noordstra I, Gupta S, Chan AH, Jones MJK, Schroder K, Yap AS (2022).
Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports Feb 1;38(5):110316. Pubmed


124. Tseng HW, Samuel SG, Schroder K, Lévesque JP, Alexander KA (2022).
Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease. Current Osteoporosis Reports Jun;20(3):170-185. Pubmed


123. Coll RC, Schroder K, Pelegrin P (2022).
NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends in Pharmacological Sciences Aug;43(8):653-668. Pubmed


122. Ross C, Chan AH, von Pein JB, Maddugoda MP, Boucher D, Schroder K (2022).
Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes. Annual Review of Immunology Apr 26;40:249-269. Pubmed


121. Milner MT, Lawrence GM, Holley CL, Bodea LG, Götz J, Burgener SS, Schroder K (2022).
Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols Apr 11;3(2):101295. Pubmed


120. Tseng HW, Kulina I, Girard D, Gueguen J, Vaquette C, Salga M, Fleming W, Jose B, Millard SM, Pettit AR, Schroder K, Thomas G, Wheeler L, Genêt F, Banzet S, Alexander KA, Levesque JP (2022).
Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. Journal of Bone and Mineral Research Mar;37(3):531-546. Pubmed


119. Schroder K, Coll RC (2021).
Caging NLRP3 tames inflammasome activity. Cell Dec 22;184(26):6224-6226. Pubmed


118. Schimmel L, Chew KY, Stocks CJ, Yordanov TE, Essebier P, Kulasinghe A, Monkman J, Dos Santos Miggiolaro AFR, Cooper C, de Noronha L, Schroder K, Lagendijk AK, Labzin LI, Short KR, Gordon EJ (2021).
Endothelial cells are not productively infected by SARS-CoV-2. Clinical & Translational Immunology Oct 24;10(10):e1350. Pubmed


117. Lucas RM, Liu L, Curson JEB, Koh YWH, Tuladhar N, Condon ND, Das Gupta K, Burgener SS, Schroder K, Ingley E, Sweet MJ, Stow JL, Luo L (2021).
SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell Reports Sep 7;36(10):109662. Pubmed


116. Richter J, Monteleone MM, Cork AJ, Barnett TC, Nizet V, Brouwer S, Schroder K, Walker MJ (2021).
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology & Cell Biology Nov;99(10):1040-1052. Pubmed


115. Richter J, Brouwer S, Schroder K, Walker MJ (2021).
Inflammasome Activation and IL-1β Signalling in Group A Streptococcus Disease. Cellular Microbiology Jun 21:e13373. Pubmed


114. Starobova H, Monteleone M, Adolphe C, Batoon L, Sandrock CJ, Tay B, Deuis JR, Smith AV, Mueller A, Nadar EI, Lawrence GP, Mayor A, Tolson E, Levesque JP, Pettit AR, Wainwright BJ, Schroder K, Vetter I (2021).
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine May 3;218(5):e20201452. Pubmed


113. Chong WC, Shastri MD, Peterson GM, Patel RP, Pathinayake PS, Dua K, Hansbro NG, Hsu AC, Wark PA, Shukla SD, Johansen MD, Schroder K, Hansbro PM (2021).
The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders. Clinical and Translational Immunology Feb 11;10(2):e1247. Pubmed


112. Burgener SS, Schroder K (2021).
Placental inflammasome signaling: Protection for mother and baby. Journal of Experimental Medicine Jan 4;218(1):e20201738. Pubmed


111. Milner MT, Maddugoda M, Götz J, Burgener SS, Schroder K (2021).
The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease. Current Opinion in Immunology Feb;68:116-124. Pubmed


110. Kapetanovic R, Afroz SF, Ramnath D, Lawrence GM, Okada T, Curson JE, de Bruin J, Fairlie DP, Schroder K, St John JC, Blumenthal A, Sweet MJ (2020).
Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology & Cell Biology Aug;98(7):528-539. Pubmed


109. Hill JR, Coll RC, Schroder K, Robertson A (2020).
Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters May 7;61(19):151849. ScienceDirect


108. Holley CL, Schroder K (2020).
The rOX-stars of inflammation: links between the inflammasome and mitochondrial meltdown. Clinical and Translational Immunology 2020 Feb 10; 9(2): e01109. Pubmed


107. Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, Quaife-Ryan GA, Al-Sharea A, Pernes G, Dragoljevic D, Lal H, Schroder K, Hanaoka BY, Raman C, Grant MB, Hudson JE, Smyth S, Porrello ER, Murphy AJ, Nagareddy PR (2020).
Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis Following Myocardial Infarction. Circulation 2020 Mar 31;141(13):1080-1094. Pubmed


106. Chan AH, Schroder K (2020).
Inflammasome signaling and regulation of interleukin-1 family cytokines. Journal of Experimental Medicine Jan 6;217(1):e20190314. Pubmed


105. Burgener SS, Schroder K (2020).
Neutrophil Extracellular Traps in Host Defense. Cold Spring Harbor Perspectives in Biology Jul 1;12(7):a037028. Pubmed


104. Deora V, Lee JD, Albornoz EA, McAlary L, Jagaraj CJ, Robertson AAB, Atkin JD, Cooper MA, Schroder K, Yerbury JJ, Gordon R, Woodruff TM (2020).
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia Feb;68(2):407-421. Pubmed


103. Emming S, Schroder K (2019).
Tiered DNA sensors for escalating responses. Science Sep 27;365(6460):1375-1376. Pubmed

Find also:
Summary from Science, Reprint from Science, and Full text from Science


102. Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Hall P, Sklar LA, Allers L, Mariscal L, Garcia SA, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Jo EK, Johansen T, Juhász G, Kimchi A, Ktistakis N, Kroemer G, Mizushima N, Münz C, Reggiori F, Rubinsztein D, Ryan K, Schroder K, Shen HM, Simonsen A, Tooze SA, Vaccaro M, Yoshimori T, Yu L, Zhang H, Klionsky DJ (2019).
Autophagy, Inflammation, and Metabolism (AIM) Center in its second year. Autophagy Oct;15(10):1829-1833. Pubmed


101. Loh Z, Fitzsimmons RL, Reid RC, Ramnath D, Clouston A, Gupta PK, Irvine KM, Powell EE, Schroder K, Stow JL, Sweet MJ, Fairlie DP, Iyer A (2019).
Inhibitors Of Class I Histone Deacetylases Attenuate Thioacetamide-Induced Liver Fibrosis In Mice By Suppressing Hepatic Type 2 Inflammation. British Journal of Pharmacology 2019 Oct;176(19):3775-3790. Pubmed


100. Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB, Schroder K (2019).
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology 15(6):556-559. PDF Pubmed

Research highlight:
Walking over the inflammasome. Gorka O, Neuwirt E, Gross O (2019). Nature Chemical Biology Jun;15(6):552-553. PDF Pubmed


99. Murthy AMV, Sullivan MJ, Nhu NTK, Lo AW, Phan MD, Peters KM, Boucher D, Schroder K, Beatson SA, Ulett GC, Schembri MA, Sweet MJ (2019).
Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent versus -independent macrophage cell death and host colonization. FASEB Journal Jun;33(6):7437-7450 Pubmed


98. Skinner OP, Jurczyluk J, Baker PJ, Masters SL, Rios Wilks AG, Clearwater MS, Robertson AAB, Schroder K, Mehr S, Munoz MA, Rogers MJ (2019).
Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes. Journal of Allergy and Clinical Immunology Jun;143(6):2315-2317. Pubmed


97. Bierschenk D, Monteleone M, Moghaddas F, Baker PJ, Masters SL, Boucher D, Schroder K (2019).
The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses. Journal of Leukocyte Biology 105(2):401-410. Pubmed


96. Ross C, Chan AH, Von Pein J, Boucher D, Schroder K (2018).
Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome. Life Science Alliance Dec 6;1(6):e201800237. Pubmed


95. Holley CL, Coll RC, Schroder K (2018).
NLRC3 Restrains Responses to a T. Immunity Dec 18;49(6):989-991. Pubmed

Comment on:
The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Uchimura T et al (2018). Immunity Dec 18;49(6):1049-1061. Pubmed


94. Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM (2018).
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine Oct 31;10(465):eaah4066. Pubmed


93. Coll RC, Holley CL, Schroder K (2018).
Mitochondrial DNA synthesis fuels the NLRP3 inflammasome. Cell Research Nov;28(11):1046-1047. Pubmed

Comment on:
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Zhong Z et al (2018). Nature Aug;560(7717):198-203. Pubmed


92. Chen KW1, Monteleone M1, Boucher D1, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K (2018).
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps. Science Immunology Aug 24;3(26):eaar6676. Pubmed Full-text from Science Immunology

1Equal contribution

Research highlight:
Gasdermin D opens the way for NETs. Spel L, Martinon F (2018). Nature Reviews Rheumatology Dec;14(12):690-692. Pubmed


91. Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K (2018).
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion. Cell Reports Aug 7;24(6):1425-1433. Pubmed


90. Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ (2018).
Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight Jul 25;3(14):120274. Pubmed


89. Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Sklar LA, Allers L, Garcia SA, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Hotamisligi G, Jäättelä M, Jo EK, Johansen T, Juhász G, Kimchi A, Ktistakis N, Kroemer G, MIzushima N, Münz C, Reggiori F, Rubinsztein D, Ryan K, Schroder K, Simonsen A, Tooze S, Vaccaro M, Yoshimori T, Yu L, Zhang H, Klionsky DJ (2018).
Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy 14(6):925-929. Pubmed


88. Perera AP, Fernando R, Shinde T, Gundamaraju R, Southam B, Sohal SS, Robertson AAB, Schroder K, Kunde D, Eri R (2018).
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports Jun 5;8(1):8618. Pubmed


87. Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica J, Vince JE, Schroder K (2018).
Cutting edge: IAP inhibition sensitizes neutrophils to TNF but not LPS-mediated cell death and IL-1β secretion. Journal of Immunology May 15;200(10):3341-3346. Pubmed


86. Gambin Y, Giles N, O'Carroll A, Polinkovsky ME, Johnston W, Hunter DJB, Alexandrov K, Schroder K, Sierecki E (2018).
Single-Molecule Fluorescence Reveals the Oligomerisation and Folding Steps Driving the Prion-like Behaviour of ASC. Journal of Molecular Biology Feb 16;430(4):491-508. Pubmed


85. Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW (2018).
Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research Mar 23;4(1). Pubmed


84. Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine Mar 5;215(3):827-840. Pubmed

1Equal contribution

See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has received
Read news articles here

Research highlight:
Defusing inflammasomes. Sandstrom A, Vance RE (2018). Journal of Experimental Medicine Mar 5;215(3):723-724. Pubmed


83. James KR, Soon MSF, Sebina I, Fernandez-Ruiz D, Davey G, Liligeto UN, Nair AS, Fogg LG, Edwards CL, Best SE, Lansink LIM, Schroder K, Wilson JAC, Austin R, Suhrbier A, Lane SW, Hill GR, Engwerda CR, Heath WR, Haque A (2018).
IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection. Journal of Immunology Feb 15;200(4):1443-1456. Pubmed


82. Boucher D, Chan A, Ross C, Schroder K (2018).
Quantifying Caspase-1 Activity in Murine Macrophages. Methods in Molecular Biology 1725:163-176. Pubmed


81. Schroder K, Kanneganti TD, Shao F, Broz P (2018).
Mechanisms and Consequences of Inflammasome Activation. Journal of Molecular Biology Jan 19;430(2):131-132. Pubmed


80. Hill JR, Coll RC, Sue N, Reid JC, Dou J, Holley CL, Pelingon R, Dickinson JB, Biden TJ, Schroder K, Cooper MA, Robertson AAB (2017).
Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors. Chem Med Chem Sep 7;12(17):1449-1457. Pubmed


79. Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE (2017).
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation. Cell Reports Jul 18;20(3):668-682. Pubmed


78. Mridha AR, Wree A, Robertson AA, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC (2017).
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology 2017 May;66(5):1037-1046. Pubmed

Research highlight:
A critical role for the NLRP3 inflammasome in NASH. Thomas H (2017). Nature Reviews Gastroenterology and Hepatology Apr;14(4):197. Nature


77. Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE (2017).
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A Feb7;114(6):E961-969. Pubmed


76. Bezbradica JS1, Coll R1, Schroder K (2017).
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular & Molecular Immunology. 14:118-126. Pubmed

1Joint contribution


75. Deuis JR, Yin K, Cooper MA, Schroder K, Vetter I (2017).
Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns Mar;43(2):304-309. Pubmed


74. Bezbradica JS, Schroder K (2017).
Zebrafish earns its stripes for in vivo ASC speck dynamics. Journal of Cell Biology Sep 4;216(9):2615-2618. Pubmed


73. Duszyc K, Gomez GA, Schroder K, Sweet MJ, Yap AS (2017).
In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis. Tissue Barriers Oct 2;5(4):e1345353. Pubmed


72. Bierschenk D, Boucher D, Schroder K (2017).
Salmonella-induced inflammasome activation in humans. Molecular Immunology Jun;86:38-43. Pubmed


71. Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AA, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O (2016).
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity Oct 18;45(4):761-773. Pubmed


70. Sester DP, Zamoshnikova A, Thygesen SJ, Vajjhala PR, Cridland SO, Schroder K, Stacey KJ (2016).
Assessment of inflammasome formation by flow cytometry. Current Protocols in Immunology Aug1;114:14.40.1-14.40.29. Pubmed


69 Le TT, Skak K, Schroder K, Schroder WA, Boyle GM, Pierce CJ, Suhrbier A (2016).
IL-1 contributes to the anti-cancer efficacy of ingenol mebutate. PLoS One Apr 21;11(4):e0153975. Pubmed


68. Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A (2016).
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. Science Translational Medicine Mar 30;8(332):332ra45. Pubmed

Research highlight:
Mutation implicated in auto-inflammatory disease. El-Awady (2016). Nature Middle East May;581(7808):239-240. Nature Middle East


67. Kapetanovic R, Bokil NJ, Achard ME, Ong CY, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ (2016).
Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal May;30(5):1901-12. Pubmed


66. Arrifin JK, Kapetanovic R, Schaale K, Gatica-Andrades M, Blumenthal A, Schroder K, Sweet MJ (2016).
The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology Jul;100(1):155-61. Pubmed


65. Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology 46(4):1004-10. Pubmed


64. Zamoshnikova A, Groß CJ, Schuster S, Chen KW, Wilson A, Tacchini-Cottier F, Schroder K (2016).
NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology 221(2):341-6. Pubmed


63. Schaale K, Peters KM, Murthy AM, Fritzsche A, Phan MD, Totsika M, Robertson AAB, Nichols KB, Cooper MC, Stacey KJ, Ulett GC, Schroder K, Schembri MA, Sweet MJ (2016).
Strain-and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli. Mucosal Immunology 9(1):124-36. Pubmed


62. Coll R, O'Neill L, Schroder K (2016).
Questions and Controversies in innate immune research: What is the physiological role of NLRP3? Cell Death Discovery Apr 4;2:16019. Cell Death Discovery


61. Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ (2015).
The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. Journal of Biological Chemistry 290(49):29217-30. Pubmed


60. Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V (2015).
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. Journal of Cell Biology 210(6):973-89. Pubmed


59. Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. Pubmed

1, 2Joint Contribution

Research highlight:
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. Rivers-Auty J, Brough D (2015). European Journal of Immunology Oct;45(10):2758-61. Pubmed


58. Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, Masters SL, Genske U, Hornung V, Andoniou CE, Sweet MJ, Degli-Esposti MA, Schroder K, Stacey KJ (2015).
Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice. Journal of Immunology 195(3):1233-41. Pubmed


57. Zeis T, Allaman I, Gentner M, Schroder K, Tschopp J, Magistretti PJ, Schaeren-Wiemers N (2015).
Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling. Brain, Behavior, Immunity 48:313-25. Pubmed


56. Coll RC, Robertson AAB, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KHG, Masters SL, Schroder K, Cooper MA, O’Neill LAJ (2015).
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21(3):248-55. Pubmed

See Nature Medicine for a complete list of citations, reviews and media attention this publication has received
Read news articles here

Research highlight:
Inflammasome inhibition: putting out the fire. Netea MG, Joosten LAB (2015). Cell Metabolism Apr 7;21(4):513-4. Pubmed
Inflammatory diseases: Starving inflammation. Kugelberg E (2015). Nature Reviews Drug Discovery Apr;14(4):237. Nature Reviews Drug Discovery
Inflammation. Potent small molecule extinguishes the NLRP3 inflammasome. Onuora S (2015). Nature Reviews Rheumatology Apr;11(4):198. Pubmed
The Nlrp3 inflammasome admits defeat. Groß CJ, Groß O (2015). Trends in Immunology Jun;36(6):323-4. Pubmed
Inflammasome: starving inflammation. Kugelberg E (2015). Nature Reviews Immunology Apr;15(4):199. Pubmed
Neuroinflammation: Targeting neuroinflammation through inhibition of NLRP3. Chase A (2015). Nature Reviews Neurology Apr;11(4):186. Nature Reviews Neurology
Taming the Inflammasome. Levy M, Thaiss CA, Elinav E (2015). Nature Medicine Mar;21(3):213-5. Pubmed


55. Sester DP, Thygesen SJ, Sagulenko V, Vajjhala PR, Cridland JA, Vitak N, Chen KW, Osborne GW, Schroder K, Stacey KJ (2015).
A novel flow cytometric method to assess inflammasome formation. Journal of Immunology 194(1):455-462. Pubmed


54. Monteleone M, Stow J, Schroder K (2015).
Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine 74(2):213-8. Pubmed


53. Boucher DB, Chen KW, Schroder K (2015).
Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2: 1-6. Inflammasome


52. Chen KW, Gross CJ, Sotomayor F, Stacey KJ, Tschopp J, Sweet MJ, Schroder K (2014).
The neutrophil NLRC4 inflammasome selectively promotes IL-1b maturation without pyroptosis during acute Salmonella challenge. Cell Reports 8: 570-582. Pubmed


51. Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL (2014).
Rab8a interacts directly with PI3Kg to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications 5:4407. Pubmed


50. Traini M, Quinn CM, Sandoval C, Johansson E, Schroder K, Kockx M, Meikle PJ, Jessup W, Kritharides L (2014).
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. Journal of Biological Chemistry 289: 32895-32913. Pubmed


49. Bezbradica JS, Schroder K (2014).
TRAF6 is a nexus for TLR-STAT1 crosstalk. Immunology and Cell Biology 92: 737-738. Pubmed

Comment on:
STAT1 plays a role in TLR signal transduction and inflammatory responses. Luu K et al (2014). Immunology and Cell Biology Oct;92(9):761-9. Pubmed


48. Chen KW, Richards AA, Zamoshnikova A, Schroder K (2014).
Inflammasomes and inflammation. Chapter 8 in Cancer and Inflammation Mechanisms, Y. Hiraku, S. Kawanishi, H. Ohshima (Editors). (USA: John Wiley and Sons, Inc). Wiley


47. Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ (2013).
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation 20: 1149-1160. Pubmed

Research highlight:
dsDNA ASCs for caspase 8-mediated apoptosis. Grabinger T, Peterburs P, Brunner T (2013). Cell Death and Differentiation Sep;20(9):1128-30. Pubmed
Another twist in the on and off affair between cell suicide and inflammation. Vaux DL (2013). Cell Death and Differentiation Aug;20(8):974-5. Pubmed


46. Achard MES, Chen KW, Sweet MJ, Watts RE, Schroder K, Schembri MA, McEwan AG (2013).
An antioxidant role for catecholate siderophores in Salmonella. Biochemical Journal 454: 543-549. Pubmed


45. Shakespear MR, Hohenhaus DM, Kelly GM, Kamal NA, Gupta P, Labzin LI, Schroder K, Garceau V, Barbero S, Iyer A, Hume DA, Reid RC, Irvine KM, Fairlie DP, Sweet MJ (2013).
Histone deacetylase 7 promotes toll-like receptor 4-dependent proinflammatory gene expression in macrophages. Journal of Biological Chemistry 288: 25362-25374. Pubmed


44. Chen K, Richards AA, Caradoc-Davies TT, Vajjhala PR, Robin G Lua LHL, Hill JH, Schroder K, Sweet MJ, Kellie S, Kobe B, Martin JL (2013).
Human BinCARD splice isoforms have differing localizations and their CARD structure reveals a possible redox role. Acta Crystallographica D 69: 774-784. Pubmed


43. Chen KW, Schroder K (2013).
Antimicrobial functions of inflammasomes. Current Opinion in Microbiology 16: 311-318. Pubmed


42. Thomas CJ, Schroder K (2013).
Pattern recognition receptor function in neutrophils. Trends in Immunology 34:317-328. Pubmed


41. Schroder K and Deretic V (2013).
Innate immunity, the constant gardener of antimicrobial defence. Current Opinion in Microbiology 16: 293-295. Pubmed


40. Schroder K, Sagulenko V, Zamoshnikova A, Richards AA, Cridland JA, Irvine KM, Stacey KJ, Sweet MJ (2012).
Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology 217: 1325-1329. Pubmed


39. Schroder K, Irvine KM, Taylor MS, Bokil NJ, Le Cao KA, Masterman KA, Labzin LI, Semple CA, Kapetanovic R, Fairbairn L, Akalin A, Faulkner GJ, Baillie JK, Gongora M, Daub CO, Kawaji H, McLachlan GJ, Goldman N, Grimmond SM, Carninci P, Suzuki H, Hayashizaki Y, Lenhard B, Hume DA, Sweet MJ (2012).
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences U S A 109: E944-53. Pubmed

Subject of a Nature Asia commentary


38. Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, Ragan MA, Kassahn KS, Stacey KJ (2012).
The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evolutionary Biology 12: 140. Pubmed


37. Staehli F, Ludigs K, Heinz L.X, Seguin-Estevez Q, Ferrero I, Braun M, Schroder K, Rebsamen M, Tardivel A, Mattmann C, Macdonald H.R, Romero P, Reith W, Guarda G, Tschopp J (2012).
NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells. Journal of Immunology 188: 3820-3828. Pubmed


36. Heinz LX, Rebsamen M, Rossi DC, Staehli F, Schroder K, Quadroni M, Gross O, Schneider P, Tschopp J (2012).
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death and Differentiation 19: 722-731. Pubmed


35. Irvine KM, Schroder K, and Powell EE (2012).
Liver repercussions of defective gut surveillance. Hepatology 56: 1174-1177. Pubmed

Comment on:
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Henao-Mejia J et al (2012). Nature Feb 1;482(7384):179-85. Pubmed


34. Heinz LX, Schroder K (2012).
Novel insights into the innate immune response to non-tuberculous Mycobacteria. Immunology and Cell Biology 90: 568-570. Pubmed

Comment on:
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1. Lee et al (2012). Immunology and Cellular Biology Jul;90(6):601-10. Pubmed


33. Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, Tschopp J (2011).
Differential expression of NLRP3 among hematopoietic cells. Journal of Immunology 186: 2529-2534. Pubmed


32. van Zuylen WJ, Garceau V, Idris A, Schroder K, Irvine KM, Lattin JE, Ovchinnikov DA, Perkins AC, Cook AD, Hamilton JA, Hertzog PJ, Stacey KJ, Kellie S, Hume DA, Sweet MJ (2011).
Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One 6 e15723. Pubmed


31. Kawaji H, Severin J, Lizio M, Forrest AR, van Nimwegen E, Rehli M, Schroder K, Irvine K, Suzuki H, Carninci P, Hayashizaki Y, Daub CO (2011).
Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research 39: D856-860. Pubmed


30. Low PC, Misaki R, Schroder K, Stanley AC, Sweet MJ, Teasdale RD, Vanhaesebroeck B, Meunier FA, Taguchi T, Stow JL (2010).
Phosphoinositide 3-kinase delta regulates membrane fission of Golgi carriers for selective cytokine secretion. Journal of Cell Biology 190: 1053-1065. Pubmed


29. Kubosaki A, Lindgren G, Tagami M, Simon C, Tomaru Y, Miura H, Suzuki T, Arner E, Forrest AR, Irvine KM, Schroder K, Hasegawa Y, Kanamori-Katayama M, Rehli M, Hume DA, Kawai J, Suzuki M, Suzuki H, Hayashizaki Y (2010).
The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology 47: 2295-2302. Pubmed


28. Halili MA, Andrews MR, Labzin LI, Schroder K, Matthias G, Cao C, Lovelace E, Reid RC, Le GT, Hume DA, Irvine KM, Matthias P, Fairlie DP, Sweet MJ (2010).
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology 87: 1103-1114. Pubmed


27. Schroder K, Tschopp J (2010).
The inflammasomes. Cell 140: 821-832. Pubmed


26. Schroder K, Zhou R, Tschopp J (2010).
The NLRP3 inflammasome: a sensor for metabolic danger? Science 327: 296-300. Pubmed


25. Tschopp J, Schroder K (2010).
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology 10: 210-215. Pubmed


24. Hume DA, Schroder K, Irvine K (2010).
The impact of CAGE data on the understanding of macrophage transcriptional biology. Chapter 17 in Cap-Analysis Gene Expression (CAGE) - the Science of Decoding Genes Transcription, P. Carninci (Editor). (Singapore: Pan Stanford Publishing). Pan Stanford Publishing


23. Taft RJ, Glazov EA, Cloonan N, Simons C, Stephen S, Faulkner GJ, Lassmann T, Forrest AR, Grimmond SM, Schroder K, Irvine K, Arakawa T, Nakamura M, Kubosaki A, Hayashida K, Kawazu C, Murata M, Nishiyori H, Fukuda S, Kawai J, Daub CO, Hume DA, Suzuki H, Orlando V, Carninci P, Hayashizaki Y, Mattick JS (2009).
Tiny RNAs associated with transcription start sites in animals. Nature Genetics 41: 572-578. Pubmed


22. Faulkner GJ, Kimura Y, Daub CO, Wani S, Plessy C, Irvine KM, Schroder K, Cloonan N, Steptoe AL, Lassmann T, Waki K, Hornig N, Arakawa T, Takahashi H, Kawai J, Forrest AR, Suzuki H, Hayashizaki Y, Hume DA, Orlando V, Grimmond SM, Carninci P (2009).
The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics 41: 563-571. Pubmed


21. FANTOM4 International Consortium: Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Bjorkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engstrom PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hornquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schonbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegner J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y (2009).
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics 41: 553-562. Pubmed


20. Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J (2009).
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Reports 10: 916-922. Pubmed


19. Mar JC, Kimura Y, Schroder K, Irvine KM, Hayashizaki Y, Suzuki H, Hume D, Quackenbush J (2009).
Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics 10: 110. Pubmed


18. Irvine KM, Andrews MR, Fernandez-Rojo MA, Schroder K, Burns CJ, Su S, Wilks AF, Parton RG, Hume DA, Sweet MJ (2009).
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology 85: 278-288. Pubmed


17. Schroder K, Muruve DA, Tschopp J (2009).
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Current Biology 19: R262-265. Pubmed


16. Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, Lo YL, Manzanero S, Cobbold C, Schroder K, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume DA, Stow J, Blanchard H, Ashman RB (2008).
The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology 180: 7404-7413. Pubmed


15. Maeda N, Nishiyori H, Nakamura M, Kawazu C, Murata M, Sano H, Hayashida K, Fukuda S, Tagami M, Hasegawa A, Murakami K, Schroder K, Irvine K, Hume D, Hayashizaki Y, Carninci P, Suzuki H (2008).
Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. Biotechniques 45: 95-97. Pubmed


14. Lattin JE, Schroder K, Su AI, Walker JR, Zhang J, Wiltshire T, Saijo K, Glass CK, Hume DA, Kellie S, Sweet MJ (2008).
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Research 4: 5. Pubmed


13. Faulkner GJ, Forrest AR, Chalk AM, Schroder K, Hayashizaki Y, Carninci P, Hume DA, Grimmond SM (2008).
A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics 91: 281-288. Pubmed


12. Chang MK, Raggatt LJ, Alexander KA, Kuliwaba JS, Fazzalari NL, Schroder K, Maylin ER, Ripoll VM, Hume DA, Pettit AR (2008).
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. Journal of Immunology 181: 1232-1244. Pubmed


11. Schroder K, Spille M, Pilz A, Lattin J, Bode KA, Irvine KM, Burrows AD, Ravasi T, Weighardt H, Stacey KJ, Decker T, Hume DA, Dalpke AH, Sweet MJ (2007).
Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology 179: 3495-3503. Pubmed


10. Schroder K, Lichtinger M, Irvine KM, Brion K, Trieu A, Ross IL, Ravasi T, Stacey KJ, Rehli M, Hume DA, Sweet MJ (2007).
PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology 81: 1577-1590. Pubmed


9. Bode KA, Schroder K, Hume DA, Ravasi T, Heeg K, Sweet MJ, Dalpke AH (2007).
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122: 596-606. Pubmed


8. Lattin J, Zidar DA, Schroder K, Kellie S, Hume DA, Sweet MJ (2007).
G-protein-coupled receptor expression, function, and signaling in macrophages. Journal of Leukocyte Biology 82: 16-32. Pubmed


7. Wells CA, Chalk AM, Forrest A, Taylor D, Waddell N, Schroder K, Himes SR, Faulkner G, Lo S, Kasukawa T, Kawaji H, Kai C, Kawai J, Katayama S, Carninci P, Hayashizaki Y, Hume DA, Grimmond SM (2006).
Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology 7:R10. Pubmed


6. Aung HT1, Schroder K1, Himes SR, Brion K, van Zuylen W, Trieu A, Suzuki H, Hayashizaki Y, Hume DA, Sweet MJ, Ravasi T (2006).
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB Journal 20:1315-1327. Pubmed

1Joint contribution


5. Schroder K, Sweet MJ, Hume DA (2006).
Signal integration between IFNgamma and TLR signalling pathways in macrophages. Immunobiology 211: 511-524. Pubmed


4. Sester DP, Trieu A, Brion K, Schroder K, Ravasi T, Robinson JA, McDonald RC, Ripoll V, Wells CA, Suzuki H, Hayashizaki Y, Stacey KJ, Hume DA, Sweet MJ (2005).
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology 210: 97-107. Pubmed


3. Ravasi T, Hsu K, Goyette J, Schroder K, Yang Z, Rahimi F, Miranda LP, Alewood PF, Hume DA, Geczy C (2004).
Probing the S100 protein family through genomic and functional analysis. Genomics 84, 10-22. Pubmed


2. Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004).
Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology 75:163-189. Pubmed


1. Leung D, Schroder K, White H, Fang NX, Stoermer MJ, Abbenante G, Martin JL, Young PR, Fairlie DP (2001).
Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. Journal of Biological Chemistry 276:45762-71. Pubmed




3. O'Neill LA, Coll RC, Cooper MA, Robertson AAB, Schroder K. MacLeod AM, Miller DJ.
Novel compounds and uses. PCT/IB2017/053059, Filing: 24/05/2017.


2. O'Neill LA, Coll RC, Cooper MA, Robertson AAB, Schroder K. MacLeod AM, Miller DJ.
Sulfonylureas and related compounds and use of same. PCT/EP2017/053498, Filing: 16/02/2017.


1. O'Neill LA, Coll RC, Cooper MA, Robertson AAB, Schroder K.
Sulfonylureas and related compounds and use of same. PCT/AU2016/050103, Filing: 16/02/2016.