About Us

 

 

In the animated film, The Inflammasome signalling pathway, A/Prof Kate Schroder explains the signal transduction pathway of inflammasomes - molecular machines at the heart of host defence, inflammation and disease.

 

INFLAMMASOME LAB

During injury or infection, our body’s immune system protects us by launching inflammation. But uncontrolled inflammation drives diseases such as gout, diabetes, neurodegenerative disease and cancer. The Inflammasome Lab is defining the molecular and cellular processes of inflammation. We seek to unravel the secrets of inflammasomes – protein complexes at the heart of inflammation and disease – to allow for new therapies to fight human diseases.

 

MEET THE TEAM


Find out more about our award-winning researchers

A/Prof Kate Schroder

Principal Investigator

As well as leading the Inflammasome Lab, Kate is Deputy Director of the IMB Centre for Inflammation and Disease Research, and an ARC Future Fellow. During her career, Kate has published >50 original research articles, and has attracted research funding totalling more than $6 million. Read more

Dr Rebecca Coll

PostDoc

Rebecca joined the lab as a PostDoc in 2014. Rebecca's first primary author article in Nature Medicine has been widely acclaimed and is already highly cited since its release in March 2015. Rebecca recently discovered that our immune cells triage danger signals.
Read more

Dr Dave Boucher

PostDoc

Dave received The University of Queensland PostDoctoral Fellowship in 2014 to pursue his research in the Inflammasome Lab. He is interested in understanding how proteases are involved in health and disease and has a particular crush on caspases.
Read more

 

Dr Mercedes Monteleone

PostDoc

Mercedes joined the Inflammasome Lab as a Postdoctoral researcher in 2014 after completing her PhD at The Centenary Institute of Cancer Medicine and Cell Biology in Sydney. Mercedes is a microbiologist currently researching host-pathogen interactions.
 

 

Dr Kaiwen Chen

PostDoc

Kaiwen completed his PhD in the Inflammasome lab between 2011 and 2015, during which time he contributed to 6 publications, including 4 first author. He continues his research characterising inflammasome functions in neutrophils, as a Postdoctoral researcher. Read more

Damiën Bierschenk

PhD student

Damiën has a Masters degree in Biomedicine from the Karolinska Institute, Sweden and a Bachelor in Life Sciences, The Netherlands. In late 2014, Damiën began his PhD in the Inflammasome Lab, where he is investigating inflammasome activation by Salmonella. Read more

 

Caroline Holley

PhD student

Caroline joined the Inflammasome Lab in 2014 as an Honours student and was awarded a First Class Honours for her research project in December 2014. She returned to the lab in January 2015 as a Research Assistant and in January 2017 she started her PhD. Read more

 

 

Amy Chan

PhD student

Amy joined the Inflammasome Lab in 2016 as a PhD student. Her research project aims to unravel the mysteries of the 'non-canonical' inflammasome. Read more

Jennifer Dou

Research Assistant

Jennifer (Cookie) has a BSc and extensive experience researching cellular apoptosis in mental health disorders at the NIH's Laboratory of Molecular Pathophysiology in the US. She joined the lab as a Research Assistant in January 2016. Read more

Connie Ross

Research Assistant

Connie has a BSc from UQ and received 8 awards and prizes for outstanding academic achievement during her undergraduate training. She joined the Inflammasome Lab in 2016 as an Honours student and is now a Research Assistant. Read more

Past Lab Members

In addition to our current team, Kate has supervised PostDocs, Research Assistants, postgraduate students and undergraduate research interns.
Read about our previous team members

 

INFLAMMASOME LAB IN THE NEWS


Discoveries and outstanding research achievements from the Inflammasome Lab have been featured in news articles around the world

 

 

12 July 2017, Immune detective wins national medical research award, IMB News
Dr Larisa Labzin won the National Health and Medical Research Council (NHMRC) Frank Fenner Award for being the top-ranked researcher awarded an early-career NHMRC fellowship in 2016. As part of her fellowship, Dr Labzin will spend two years working with Dr Leo James at the MRC Laboratory of Molecular Biology in Cambridge, UK, before returning to Australia to work in Associate Professor Kate Schroder’s laboratory at IMB. The award is one of the NHMRC Research Excellence Awards, which were presented at a gala dinner in Canberra on July 12.
IMB News article

 

Rebecca Coll receives Research Australia Award17 November 2016, Young immunologist awarded for impact, UQ News
Dr Rebecca Coll, a postdoc from the Inflammasome Lab, has been awarded the prestigous Research Australia Discovery Award for 2016, at the Research Australia Health and Medical Research Awards ceremony in Sydney. Rebecca received the award for her discovery of promising anti-inflammatory compounds that block the NLRP3 inflammasome. She hopes that these compounds will be used to treat patients with inflammatory disease. “I am absolutely thrilled to receive this award and feel that it recognises our fantastic collaboration between chemistry and biology which has driven this innovative research,” Dr Coll said.
UQ News article
Inflammasome Lab article

 

 

12 September 2016, UQ’s work on inflammatory disease treatment wins $22m global investment, UQ News
Research from the Inflammasome Lab performed by Dr Rebecca Coll and Dr Kate Schroder, in collaboration with Dr Avril Robertson and Professor Matt Cooper (IMB), and Professor Luke O’Neill's team (Trinity College Dublin), has attracted investment for a new start-up company to develop treatments for inflammatory disorders including Parkinson’s disease and asthma.  The €15 million (A$22 million) investment, co-led by two top global life science investment firms, Novartis Venture Fund and Fountain Healthcare Partners, is one of the largest biotech Series A investments for intellectual property originating from an Australian university.
UQ News article

 

28 October 2014, Young immunologist receives coveted award for inflammation research, IMB News
Kate Schroder was awarded the Milstein Young Investigator Award for her outstanding contributions to basic immunology research at the annual International Cytokine and Interferon Society Meeting in Melbourne. Seymour Milstein M.D. and his wife Vivian established the Milstein awards to foster interferon and cytokine research in the hope of developing new treatments for disease. “My research focuses on inflammasomes, which is a high-tech communication system that coordinates inflammatory responses by triggering production of cytokines. I feel honoured to be recognised for my research into the pathways of inflammation, and I hope to discover much more about our immune system in the future, ” Dr Schroder said.
IMB News article

 

21 November 2013, Megafauna expert is Queensland's tallest poppy, UQ News, Researchers bloom at Tall Poppy Awards, IMB News
Dr Kate Schroder was among the 11 Queensland Tall Poppy Award winners in 2013, with palaeontologist Dr Gilbert Price named the Queensland Tall Poppy of the Year. Dr Kate Schroder characterises the fundamental pathways used by the body to detect microbes and launch anti-microbial defence programs. Kate’s research is helping us to understand exactly how the body fights infection and paves the way for the development of new anti-infective agents or vaccine formulations to combat infectious disease.
UQ News article
IMB News article

 

17 September 2013, Awards recognise UQ's rising stars of research, UQ News, IMB News
Dr Kate Schroder one of 8 researchers celebrated at University of Queensland Foundation Research Excellence Awards. Kate received the award grant for her project, Pinpointing the initiation of immune response. She is researching the “inflammasome”, which activates the immune system during infection. “If we know the pathways that allow our bodies to fight infectious disease, we may be able to develop drugs to boost our natural defences,” Dr Schroder says.
UQ News article
IMB News article

 

Dr Kate Schroder from The University of Queensland on Vimeo.

 

18 August 2010, Chronic pain and immune research take top awards, UQ News
7 June 2010, IMB researchers top state with pain and immune research, IMB News
Dr Kate Schroder receives one of four awards on offer at the Queensland Health and Medical Research Awards. Dr Schroder won Postdoctoral Researcher of the Year for her work studying the innate immune system, which provides general protection against infection from invading organisms. Dr Schroder found the active genes in the mouse and human innate immune systems differ by about 20 percent. This information, and the exact genes which differ, will be useful for immunologists using mice as a model for human diseases.
UQ News article
IMB News article

 

 

 

February 2015, Scientists uncover marvel molecule that could lead to treatments for inflammatory disease
Rebecca Coll and the UQ teams led by Dr Kate Schroder and Prof Matt Cooper, together with their collaborators from the Trinity College Dublin, uncovered a marvel molecule that blocks a key driver of inflammatory diseases. The finding could meet a major unmet clinical need by inspiring new non-invasive treatments for arthritis, multiple sclerosis and Muckle-Wells syndrome, among a myriad of other inflammatory diseases. In the study published in the world’s leading preclinical medical journal Nature Medicine, the researchers showed how the molecule MCC950 can suppress the NLRP3 inflammasome, which is an activator of the key process in inflammatory diseases.

Currently 24 international news articles and 4 scientific blogs have been written about the discovery including those in; The Journal (Ireland), Science Newsline, redOrbit, Today Topics, Medical News Today, The Medical News, Health Medicine Network, Drug Discovery and Development, EurekAlert!, and more. Read the news articles here.
See Nature Medicine for a complete list of citations, reviews and media attention this publication has recieved.

 

27 November 2014, Scientists uncover new intelligence behind inflammatory disease
Kaiwen Chen and the team led by Dr Kate Schroder have uncovered a secret of an immune cell on the frontline that could assist with developing new treatments for inflammatory diseases. “We have found that a type of immune cell doesn’t self-destruct like other cell types in our immunological army, and for this reason, it may be a key driver of inflammatory disease,” Dr Kate Schroder said. The discovery was published in the prestigous journal Cell Reports.
IMB News article

 

 

 

17 March 2015, New money for Queensland's Parkinson's research, DPS News
6 March 2015, University of Queensland receives grant for Parkinsons research, Future Unlimited, Australian Government
6 March 2015, New money for UQ Parkinson's research, UQ News
9 February 2015, New Queensland Research Project, Shake It Up
A UQ collaboration including Kate Schroder has been awarded a research grant from The Michael J. Fox Foundation for Parkinson's Research and its major Australian funding partner, Shake It Up Australia Foundation. The collaboration includes the teams of five UQ researchers led by Associate Professor Trent Woodruff including Dr Richard Gordon, Professor Matt Cooper, Dr Kate Schroder and Dr Avril Robertson.
DPS News article
Future Unlimited News article
UQ News article
Shake It Up News article

 

 

12 November 2014, Young researchers awarded UQ fellowships
Dave Boucher, one of three talented young researchers awarded UQ postdoctoral fellowships to support their promising research. Young immunologist Dr Dave Boucher will use his fellowship to unlock the secrets of the inflammasome – a cluster of molecules that trigger inflammation in the body. His research, performed in Dr Kate Schroder’s lab, will help us to understand how inflammasome dysfunction can contribute to chronic inflammatory disease.
IMB News article

 

20 October 2014, Imaging centre to unravel secrets of immune system, UQ News
University of Queensland researchers will play a key role in a new $39 million research centre working to unravel the secrets of the immune system. In addition to researchers from La Trobe, Monash and The University of New South Wales, UQ’s principal investigator is David Fairlie, with associate investigators Matt Sweet, Kate Schroder and Ranjeny Thomas.
UQ News article

 

21 June 2012, Diabetes and sugarcane research at IMB receives a boost, IMB News, IMB News article
19 June 2012, Diabetes and sugarcane research boosted by Queensland Government, UQ News, UQ News article
19 June 2012, UQ welcomes the govt’s science investments in the future, UQ News, UQ News article

Dr Kate Schroder receives project funding from the Queensland Government to combat type 2 diabetes, one of the fastest-growing preventable diseases in Queensland.

 

 

RESEARCH SUPPORT


Our research past and present has been generously supported by the following organisations

Inflammasome Lab funding