Inflammasomes are potent drivers of inflammatory responses, and are thus important for microbial clearance. But uncontrolled or inappropriate inflammatory responses are responsible for a wide variety of human diseases (e.g. septic shock, gout, diabetes, neurodegenerative diseases, various cancers). Cellular mechanisms of inflammasome inhibition are poorly characterised but of key importance to human health. New pharmacological approaches for inflammasome inhibition have broad potential for the treatment of human inflammatory and neurodegenerative diseases.
Image: Artwork representing inactivation of inflammasomes.
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