Inflammasomes activate caspase family proteases, and thereby trigger caspase-dependent cellular programs, such as cytokine maturation and secretion, pyroptotic cell death and apoptotic cell death. We aim to understand precisely how inflammasomes control the activity of inflammatory caspases, and the proteolytic cascades that control cellular programs such as pyroptotic cell death and unconventional protein secretion.
Image: Three-dimensional protein structures of the Caspase1 dimer. Image credit: Image generated in pymol by Dr Dave Boucher, using the 1ICE structure from the Protein Data Bank.
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